Motif ID: RXR{A,B,G}.p2

Z-value: 1.796


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRBchr6_-_33276416-0.533.4e-02Click!
RXRAchr9_+_136358145-0.243.7e-01Click!
RXRGchr1_-_163680941-0.204.5e-01Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_100270222 3.510 DLK1
delta-like 1 homolog (Drosophila)
chr6_-_132314004 3.321 NM_001901
CTGF
connective tissue growth factor
chr6_-_2916786 3.279 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr6_-_2916280 3.013 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr11_-_86343859 2.754 NM_012193
FZD4
frizzled homolog 4 (Drosophila)
chr14_-_103058568 2.578 CKB
creatine kinase, brain
chr5_-_172688024 2.320 STC2
stanniocalcin 2
chr17_-_74433048 2.229 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr17_-_74432800 2.049 TIMP2
TIMP metallopeptidase inhibitor 2
chr17_-_74432671 1.865 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_+_144040751 1.769 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr21_+_45649429 1.636 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr7_-_107430566 1.629 NM_002291
LAMB1
laminin, beta 1
chr21_+_45649719 1.609


chr5_-_131591380 1.584 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr14_+_100263028 1.579 DLK1
delta-like 1 homolog (Drosophila)
chr10_-_80875097 1.557 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr5_-_172687798 1.432 STC2
stanniocalcin 2
chr9_+_102275310 1.341 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr10_-_15453060 1.290 NM_001010924
FAM171A1
family with sequence similarity 171, member A1
chr7_-_45927263 1.236 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr9_+_36026900 1.196 NM_021111
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr3_-_121652183 1.195 NM_007085
FSTL1
follistatin-like 1
chr11_-_2118916 1.172 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr14_+_100262916 1.125 DLK1
delta-like 1 homolog (Drosophila)
chr1_+_181259317 1.120


chr6_-_33374275 1.118 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr17_-_53420473 1.094 VEZF1
vascular endothelial zinc finger 1
chr1_-_153213483 1.091 NM_001130041
NM_003029
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr6_-_128883125 1.069 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr11_+_129445057 1.066 APLP2
amyloid beta (A4) precursor-like protein 2
chr11_+_129445002 1.065 APLP2
amyloid beta (A4) precursor-like protein 2
chr1_-_153213425 1.059 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr11_+_129445017 1.052 APLP2
amyloid beta (A4) precursor-like protein 2
chr8_+_38973588 1.003 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr4_+_184257337 0.987 NM_024949
WWC2
WW and C2 domain containing 2
chr8_+_38973681 0.980 ADAM9
ADAM metallopeptidase domain 9
chr9_+_102275455 0.979 TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr14_+_100262943 0.959 NM_003836
DLK1
delta-like 1 homolog (Drosophila)
chr3_+_134947788 0.955 TF
transferrin
chr3_+_134947894 0.947 TF
transferrin
chr7_+_115953582 0.942 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr9_+_136673464 0.941 NM_000093
COL5A1
collagen, type V, alpha 1
chr3_+_134947940 0.932 TF
transferrin
chr3_+_134947573 0.929 NM_001063
TF
transferrin
chr1_-_153213454 0.925 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr6_-_2916980 0.920 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr19_+_3045528 0.911 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr19_-_54835162 0.888 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr19_-_18409971 0.888 NM_001170938
NM_016368
ISYNA1

inositol-3-phosphate synthase 1

chr17_-_37221976 0.879 NM_006455
LEPREL4
leprecan-like 4
chr8_-_122722674 0.875 NM_005328
HAS2
hyaluronan synthase 2
chr19_-_18409788 0.875 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr15_+_72005875 0.866 LOXL1
lysyl oxidase-like 1
chr15_+_72005847 0.865 LOXL1
lysyl oxidase-like 1
chr11_+_129444877 0.862 NM_001142276
NM_001142277
NM_001142278
NM_001642
APLP2



amyloid beta (A4) precursor-like protein 2



chrX_-_99778340 0.859 NM_003270
TSPAN6
tetraspanin 6
chr21_-_45532176 0.854 NM_015227
NM_133635
POFUT2

protein O-fucosyltransferase 2

chr11_-_76059435 0.852 NM_001128922
LRRC32
leucine rich repeat containing 32
chr15_+_72005839 0.851 NM_005576
LOXL1
lysyl oxidase-like 1
chr11_+_129444997 0.849 APLP2
amyloid beta (A4) precursor-like protein 2
chr15_+_72005864 0.848 LOXL1
lysyl oxidase-like 1
chr20_-_43972949 0.842 PLTP
phospholipid transfer protein
chr1_-_234295005 0.837 NID1
nidogen 1
chr20_+_42593849 0.820 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr1_-_223907283 0.810 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr14_+_100263066 0.799 DLK1
delta-like 1 homolog (Drosophila)
chr19_+_55046088 0.798 NM_017432
PTOV1
prostate tumor overexpressed 1
chr16_-_69277355 0.788 NM_138383
MTSS1L
metastasis suppressor 1-like
chr20_-_23014828 0.770 NM_012072
CD93
CD93 molecule
chr9_-_16860664 0.769 BNC2
basonuclin 2
chr5_-_55326358 0.765 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chrX_+_38305634 0.763 NM_004615
TSPAN7
tetraspanin 7
chr15_+_30797466 0.763 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr1_-_95165037 0.762 CNN3
calponin 3, acidic
chr9_-_98368913 0.756 NM_001077181
CDC14B
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr17_-_75808680 0.750 NM_000199
SGSH
N-sulfoglucosamine sulfohydrolase
chr9_-_16860719 0.747 NM_017637
BNC2
basonuclin 2
chr19_+_54708247 0.742 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr5_+_92946348 0.740 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr17_-_53420595 0.728 NM_007146
VEZF1
vascular endothelial zinc finger 1
chr1_+_181258952 0.727 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr17_+_37222726 0.727 FKBP10
FK506 binding protein 10, 65 kDa
chr22_+_36531059 0.727 NM_005318
H1F0
H1 histone family, member 0
chr7_+_142788521 0.718 ZYX
zyxin
chr4_-_81213207 0.714


chr8_+_70567581 0.706 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr11_+_10283171 0.700 NM_001124
ADM
adrenomedullin
chr9_-_13269562 0.698 MPDZ
multiple PDZ domain protein
chr12_+_50631704 0.691 NM_004302
NM_020328
ACVR1B

activin A receptor, type IB

chr17_-_38427957 0.683 NM_006373
VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr17_-_38427928 0.680 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr15_-_46725087 0.672 NM_000138
FBN1
fibrillin 1
chr14_-_103058865 0.671 NM_001823
CKB
creatine kinase, brain
chr22_-_17891777 0.670 CLDN5
claudin 5
chr3_-_38666122 0.663 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr7_-_124192265 0.660 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr1_+_43769065 0.658 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr20_+_34603311 0.655 MYL9
myosin, light chain 9, regulatory
chr12_+_79634820 0.653 NM_005593
MYF5
myogenic factor 5
chr17_-_38427853 0.650 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr7_-_149669622 0.649 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr12_-_53099203 0.638 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_-_59020875 0.638 JUN
jun proto-oncogene
chr6_-_33374713 0.637 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr7_-_94123413 0.636 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr8_+_9450849 0.630 NM_003747
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr17_+_37222487 0.625 NM_021939
FKBP10
FK506 binding protein 10, 65 kDa
chr15_-_88148177 0.624 ANPEP
alanyl (membrane) aminopeptidase
chr6_-_33374723 0.624 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr17_+_37222731 0.623 FKBP10
FK506 binding protein 10, 65 kDa
chr14_+_95575319 0.620 C14orf132
chromosome 14 open reading frame 132
chr7_+_142788480 0.618 NM_001010972
NM_003461
ZYX

zyxin

chr19_+_54723044 0.616 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr11_-_27698800 0.615 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr7_-_94123308 0.612 SGCE
sarcoglycan, epsilon
chr13_+_109936080 0.599 COL4A2
collagen, type IV, alpha 2
chr11_+_440346 0.592 PTDSS2
phosphatidylserine synthase 2
chr12_-_49706190 0.589 NM_001174129
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr13_+_31503436 0.588 NM_023037
FRY
furry homolog (Drosophila)
chr16_+_66129481 0.587 FAM65A
family with sequence similarity 65, member A
chr7_+_129497572 0.586 NM_014997
KLHDC10
kelch domain containing 10
chr11_+_440260 0.582 NM_030783
PTDSS2
phosphatidylserine synthase 2
chr4_-_86106567 0.582 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr20_-_25514137 0.582 NM_025176
NINL
ninein-like
chr14_+_23937766 0.574 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr17_-_37828643 0.572 NM_012232
PTRF
polymerase I and transcript release factor
chr12_-_105165805 0.570 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr6_-_33374678 0.568 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr2_-_202024472 0.564 NM_015049
TRAK2
trafficking protein, kinesin binding 2
chr15_-_46724360 0.564 FBN1
fibrillin 1
chr7_+_142788579 0.563 ZYX
zyxin
chr17_-_33179118 0.562 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr20_+_52525538 0.559 NM_018431
DOK5
docking protein 5
chr19_+_54708302 0.556 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr10_+_94439658 0.556 NM_002729
HHEX
hematopoietically expressed homeobox
chr19_+_55046229 0.554 PTOV1
prostate tumor overexpressed 1
chr17_+_39619826 0.552 NM_001076674
NM_024107
TMUB2

transmembrane and ubiquitin-like domain containing 2

chr5_+_141468569 0.551 NDFIP1
Nedd4 family interacting protein 1
chr5_-_87600371 0.550 NM_153354
TMEM161B
transmembrane protein 161B
chr15_-_88148538 0.548 ANPEP
alanyl (membrane) aminopeptidase
chr7_+_142788569 0.544 ZYX
zyxin
chr15_+_37660568 0.544 NM_003246
THBS1
thrombospondin 1
chr7_+_142788566 0.543 ZYX
zyxin
chr21_-_45117989 0.543 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr3_+_23962518 0.541 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr21_-_45118026 0.540 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr9_-_115880366 0.539 AMBP
alpha-1-microglobulin/bikunin precursor
chrX_+_135057202 0.539 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr2_+_27127994 0.535 NM_001035507
NM_021831
AGBL5

ATP/GTP binding protein-like 5

chr7_+_142788517 0.530 ZYX
zyxin
chr17_+_39620099 0.529 NM_177441
TMUB2
transmembrane and ubiquitin-like domain containing 2
chr5_+_109053628 0.527 MAN2A1
mannosidase, alpha, class 2A, member 1
chr15_+_67239853 0.527 NM_015554
GLCE
glucuronic acid epimerase
chr7_+_93977267 0.527 CASD1
CAS1 domain containing 1
chr3_-_50335113 0.522 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr5_+_141468568 0.517 NDFIP1
Nedd4 family interacting protein 1
chr2_+_27128024 0.516 AGBL5
ATP/GTP binding protein-like 5
chr13_+_109757593 0.516 NM_001846
COL4A2
collagen, type IV, alpha 2
chr21_-_45118037 0.515 NM_004339
PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr3_+_33293915 0.513 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr20_-_3097070 0.512 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr12_-_49706364 0.511 NM_000617
NM_001174126
NM_001174127
NM_001174128
SLC11A2



solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2



chr22_+_36422940 0.509 NM_001039141
TRIOBP
TRIO and F-actin binding protein
chr20_-_43972982 0.508 PLTP
phospholipid transfer protein
chr11_-_63689780 0.508 MACROD1
MACRO domain containing 1
chr16_-_30042030 0.508 MAPK3
mitogen-activated protein kinase 3
chr7_+_93976927 0.508 NM_022900
CASD1
CAS1 domain containing 1
chr1_+_7767300 0.506 NM_016831
PER3
period homolog 3 (Drosophila)
chr6_-_46566969 0.505 RCAN2
regulator of calcineurin 2
chr20_+_62158882 0.504 NM_198723
TCEA2
transcription elongation factor A (SII), 2
chr6_-_37061902 0.502 MTCH1
mitochondrial carrier homolog 1 (C. elegans)
chr19_+_54708312 0.493 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr3_-_51968995 0.492 PCBP4
poly(rC) binding protein 4
chr19_+_447453 0.492 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr3_+_50281582 0.490 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr12_-_46684551 0.487 NM_001844
NM_033150
COL2A1

collagen, type II, alpha 1

chr21_-_45117960 0.481 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr13_-_95503566 0.480 NM_020121
UGGT2
UDP-glucose glycoprotein glucosyltransferase 2
chr17_-_60088459 0.476 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr20_+_62164900 0.476 TCEA2
transcription elongation factor A (SII), 2
chr16_-_30042083 0.474 NM_001040056
NM_001109891
NM_002746
MAPK3


mitogen-activated protein kinase 3


chrX_-_119487164 0.469 LAMP2
lysosomal-associated membrane protein 2
chr6_-_37061897 0.469 MTCH1
mitochondrial carrier homolog 1 (C. elegans)
chr21_+_39099624 0.468 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr9_+_35782405 0.464 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr19_-_54350457 0.464 NM_002152
HRC
histidine rich calcium binding protein
chr20_+_43952189 0.464 CTSA
cathepsin A
chr1_-_94475504 0.461 ARHGAP29
Rho GTPase activating protein 29
chr7_+_142788730 0.461 ZYX
zyxin
chrX_-_119487096 0.461 LAMP2
lysosomal-associated membrane protein 2
chr16_+_57055494 0.458 NM_001130487
NDRG4
NDRG family member 4
chr21_+_39099717 0.458 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr8_-_93184629 0.457 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr1_-_36562341 0.457 NM_018166
FAM176B
family with sequence similarity 176, member B
chr7_-_94123362 0.456 SGCE
sarcoglycan, epsilon
chr17_+_39620108 0.456 TMUB2
transmembrane and ubiquitin-like domain containing 2
chr11_-_2118743 0.455 IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_+_30223304 0.455 YPEL5
yippee-like 5 (Drosophila)
chr5_+_141468498 0.451 NM_030571
NDFIP1
Nedd4 family interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.58 7.64e-04 GO:0016192 vesicle-mediated transport
1.41 2.68e-03 GO:0051641 cellular localization
1.43 5.23e-03 GO:0051649 establishment of localization in cell
1.25 5.32e-03 GO:0006810 transport
1.36 5.51e-03 GO:0009653 anatomical structure morphogenesis
1.24 6.74e-03 GO:0051234 establishment of localization
3.23 8.30e-03 GO:0010594 regulation of endothelial cell migration
1.88 8.45e-03 GO:0001568 blood vessel development
1.79 3.60e-02 GO:0001944 vasculature development
1.91 4.00e-02 GO:0048514 blood vessel morphogenesis
1.20 4.53e-02 GO:0051179 localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 8.81e-04 GO:0016020 membrane
1.72 3.47e-03 GO:0048471 perinuclear region of cytoplasm
1.44 1.60e-02 GO:0031410 cytoplasmic vesicle
1.45 1.97e-02 GO:0031988 membrane-bounded vesicle
1.45 2.03e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.43 2.06e-02 GO:0031982 vesicle

Nothing significant found in function category.